Our study suggests a possible association between epigenetic regulation of inflammatory mediators of visceral adipose tissue (VAT) in the context of colorectal cancer (CRC). This situation could be regulated, in part, by serum 25 (OH) D, as we observed an association between IL6 methylation and CRC risk, through 25 (OH) D. IL6 expression in VAT is a good prognostic factor for CRC, suggesting that IL6 could be an interesting target at HAT levels for CRC prevention.

Avalaible at: https://pubmed.ncbi.nlm.nih.gov/34549226/