MicroRNAs (miRNAs) regulate the expression of genes associated with the development of diseases, including type 2 diabetes mellitus (T2DM). However, the use of miRNAs to predict T2DM remission has been poorly studied. Therefore, we aimed to investigate whether circulating miRNAs could be used to predict the probability of T2DM remission in patients with coronary heart disease.

Our study suggests a possible association between epigenetic regulation of inflammatory mediators of visceral adipose tissue (VAT) in the context of colorectal cancer (CRC). This situation could be regulated, in part, by serum 25 (OH) D, as we observed an association between IL6 methylation and CRC risk, through 25 (OH) D. IL6 expression in VAT is a good prognostic factor for CRC, suggesting that IL6 could be an interesting target at HAT levels for CRC prevention.

This is the first study of its kind to report a decrease in global DNA methylation in subjects with low 25 (OH) D in the context of colorectal cancer (CRC).
 

As we know, healthy dietary habits reduce the risk of developing chronic diseases (e.g., heart disease, stroke and diabetes). A large number of studies support the preventive role of certain fruits and vegetables containing a variety of bioactive compounds in the development of these diseases. Recent findings provide evidence of how bioactive compounds (such as vitamins, lipids, miRNAs or other metabolites) present in the diet may exert their biological activity affecting consumer gene expression patterns.

In our previous blog we mentioned bioactive compounds, and surely more than one of you have heard them somewhere.

Well, bioactive compounds are molecules that are present in foods such as fruits, vegetables and milk. They are not considered nutrients, but they have a physiological effect and therefore can have a beneficial effect on health.

These compounds can be found in the supermarket, right on the fruit shelves, and as a curious fact, these molecules are related to the color of fruits, for example the blue and red of berries.

So when you feel like eating berries for their exquisite flavor, remember that they also possess bioactive compounds such as anthocyanins, which according to the research we share today, have a beneficial effect on cardiovascular health.

Obesity has reached a pandemic scale worldwide, mainly caused by changes in lifestyles that include the regular consumption of high-calorie food and a critical reduction of physical activity. There is now a growing body of evidence that suggests that epigenetic mechanisms may underlie the development of metabolic disorders associated to obesity.

En un viejo número de Science Dialy tienen un buen artículo sobre genética y uno de los «personajes históricos» más curiosos de los que se pueda hablar, la Eva mitocondrial o «primigenia»: ‘Mitochondrial Eve’: Mother of all humans lived 200,000 years ago. Esta curiosa figura –a la que más o menos apropiadamente pusieron el nombre de la primera mujer del Génesis– sería, estadísticamente hablando, el ancestro común más reciente por línea materna de todos los seres humanos que hoy en día vivimos sobre la Tierra.