Translational Interventions for Health

Foto Translational Interventions for Health

Lead researcher: Benjamín Fernández García

Research Center: Universidad de Oviedo. Dpto. de Morfología y Biología Celular y Dpto. de Biología Funcional. Grupo asociado al Instituto de Investigación Sanitaria del Principado de Asturias (ISPA). Facultad de Medicina. Avda. Julián Clavería, s/n. 33006 Oviedo. Asturias

Phone: +34985102775

Universidad de Oviedo (


Twitter: @ITSalud

The group's research activity is organized around the study of the biological response to the exercise and its implications for the prescription of physical activity and on population health, becoming three lines of research: 1) circulating microRNAs as emerging biomarkers of exercise response and adaptation; 2) The effect of exercise on the maternal epigenetic legacy mediated by circulating microRNAs; 3) Ageing and lifestyle: strategies to improve cognitive reserve.

The response to acute and chronic exercise has profound effects on gene expression and involves complex cross-communication between tissues. This coordinates the systemic effects of exercise on health. Therefore, the study of the molecular response to exercise has emerged in recent years as an essential tool to understand how this response is integrated and how it relates to health status, allowing to discover, in addition, new potential mechanisms involved in disease processes, as well as new therapeutic targets. Knowing in detail the molecular response to exercise is therefore essential to optimize exercise recommendations and explore the limits of a healthy exercise.


  • de GonzaloCalvo D, Dávalos A, Fernández-Sanjurjo M, Amado-Rodríguez L, Díaz-Coto S, Tomás-Zapico C, Montero A, García-González Á, Llorente-Cortés V, Heras ME, Boraita Pérez A, Díaz-Martínez ÁE, Úbeda N, Iglesias-Gutiérrez E. Circulating microRNAs as emerging cardiac biomarkers responsive to acute exercise. Int J Cardiol. 2018 Aug 1;264:130136. doi: 10.1016/j.ijcard.2018.02.092.


  • FernándezSanjurjo M, de Gonzalo-Calvo D, Fernández-García B, Díez-Robles S, Martínez-Canal Á, Olmedillas H, Dávalos A, Iglesias-Gutiérrez E. Circulating microRNA as Emerging Biomarkers of Exercise. Exerc Sport Sci Rev. 2018 Jul;46(3):160-171. doi: 10.1249/JES.0000000000000148.


  • ToméCarneiro J, Fernández-Alonso N, Tomás-Zapico C, Visioli F, Iglesias-Gutierrez E, Dávalos A. Breast milk microRNAs harsh journey towards potential effects in infant development and maturation. Lipid encapsulation can help. Pharmacol Res. 2018 Jun;132:21-32. doi: 10.1016/j.phrs.2018.04.003.


  • de GonzaloCalvo D, Iglesias-Gutiérrez E, Llorente-Cortés V. Epigenetic Biomarkers and Cardiovascular Disease: Circulating MicroRNAs. Rev Esp Cardiol (Engl Ed). 2017 Sep;70(9):763769. doi: 10.1016/j.rec.2017.05.013.


  • 5: DíezPlanelles C, Sánchez-Lozano P, Crespo MC, Gil-Zamorano J, Ribacoba R, González N, Suárez E, Martínez-Descals A, Martínez-Camblor P, Álvarez V, Martín-Hernández R, Huerta-Ruíz I, González-García I, Cosgaya JM, Visioli F, Dávalos A, Iglesias-Gutiérrez E, Tomás-Zapico C. Circulating microRNAs in Huntington's disease: Emerging mediators in metabolic impairment. Pharmacol Res. 2016 Jun;108:102-110. doi: 10.1016/j.phrs.2016.05.005.


  • 6: CasasAgustench P, Iglesias-Gutiérrez E, Dávalos A. Mother's nutritional miRNA legacy: Nutrition during pregnancy and its possible implications to develop cardiometabolic disease in later life. Pharmacol Res. 2015 Oct;100:322-34. doi: 10.1016/j.phrs.2015.08.017.


  • 7: de GonzaloCalvo D, Dávalos A, Montero A, García-González Á, Tyshkovska I, González-Medina A, Soares SM, Martínez-Camblor P, Casas-Agustench P, Rabadán M, Díaz-Martínez ÁE, Úbeda N, Iglesias-Gutiérrez E. Circulating inflammatory miRNA signature in response to different doses of aerobic exercise. J Appl Physiol (1985). 2015 Jul 15;119(2):12434. doi: 10.1152/japplphysiol.00077.2015.