Human Nutrition: Prevention and Epigenetics

Foto Human Nutrition: Prevention and Epigenetics

Lead researcher: Mónica Bulló Bonet

Research Center: Universitat Rovira i Virgili-Institut d’Investigació Sanitaria Pere Virgili-CIBERobn. C/Sant Llorenç 21. 43201 Reus-Tarragona

In the last  years, our research group have been focused on the study of the relationship between lifestyle, mainly diet, and the cardiometabolic health, deeply focusing on the biochemichal and molecular mechanisms that could explain this relation. Demosntrating benefits of the Mediterranean Diet and different key foods of this healthy pattern on the development of cardiovascular disease and type 2 diabetes are important contributions from our group. Moreover, we are interested in the effect of lifestyle on changes in circulating metabolome, microbiota and epigenome.More recently, and due to the relation between diet and lifestyle on mental health, we have started a new line of research aimed to identify the relationship between diet and cognitive impairment besides to characterize the mechanisms underlying this relation.

  • Canudas S, HernándezAlonso P, Galié S, Muralidharan J, Morell-Azanza L, Zalba G, García-Gavilán J, Martí A, Salas-Salvadó J, Bulló M*. Pistachio consumption modulates DNA oxidation and genes related to telomere maintenance: a crossover randomized clinical trial. Am J Clin Nutr. 2019 Jun 1;109(6):17381745. doi: 10.1093/ajcn/nqz048.

 

  • Papandreou C, HernándezAlonso P, Bulló M, RuizCanela M, Yu E, Guasch-Ferré M, Toledo E, Dennis C, Deik A, Clish C, Razquin C, Corella D, Estruch R, Ros E, Fitó M, Arós F, Fiol M, Lapetra J, Ruano C, Liang L, Martínez-González MA, Hu FB, Salas-Salvadó J. Plasma Metabolites Associated with Coffee Consumption: A Metabolomic Approach within the PREDIMED Study. Nutrients. 2019 May 8;11(5). pii: E1032. doi: 10.3390/nu11051032.

 

  • Muralidharan J, Papandreou C, SalaVila A, Rosique-Esteban N, Fitó M, Estruch R, Angel Martínez-González M, Corella D, Ros E, Razquín C, Castañer O, Salas-Salvadó J, Bulló M*. Fatty Acids Composition of Blood Cell Membranes and Peripheral Inflammation in the PREDIMED Study: A CrossSectional Analysis. Nutrients. 2019 Mar 7;11(3). pii: E576. doi: 10.3390/nu11030576.

 

  • Papandreou C, Li J, Liang L, Bulló M, Zheng Y, RuizCanela M, Yu E, Guasch-Ferré M, Razquin C, Clish C, Corella D, Estruch R, Ros E, Fitó M, Arós F, Serra-Majem L, Rosique N, Martínez-González MA, Hu FB, Salas-Salvadó J. Metabolites related to purine catabolism and risk of type 2 diabetes incidence; modifying effects of the TCF7L2-rs7903146 polymorphism. Sci Rep. 2019 Feb 27;9(1):2892. doi: 10.1038/s41598-019-39441-6.

 

  • Papandreou C, Bulló M*, RuizCanela M, Dennis C, Deik A, Wang D, Guasch-Ferré M, Yu E, Razquin C, Corella D, Estruch R, Ros E, Fitó M, Fiol M, Liang L, Hernández-Alonso P, Clish CB, Martínez-González MA, Hu FB, Salas-Salvadó J. Plasma metabolites predict both insulin resistance and incident type 2 diabetes: a metabolomics approach within the Prevención con Dieta Mediterránea (PREDIMED) study. Am J Clin Nutr. 2019 Mar 1;109(3):626-634. doi: 10.1093/ajcn/nqy262.

 

  • Papandreou C, SalaVila A, Galié S, Muralidharan J, Estruch R, Fitó M, Razquin C, Corella D, Ros E, Timiraos J, Lapetra J, Serra-Majem L, Carlos S, Castañer O, Asensio EM, Salas-Salvadó J, Bulló M*. Association Between Fatty Acids of Blood Cell Membranes and Incidence of Coronary Heart Disease. Arterioscler Thromb Vasc Biol. 2019 Apr;39(4):819825. doi: 10.1161/ATVBAHA.118.312073.

 

  • Camins A, Ettcheto M, Busquets O, Manzine PR, CastroTorres RD, Beas-Zarate C, Verdaguer E, Sureda FX, Bulló M, Olloquequi J, Auladell C, Folch J. Triple GLP1/GIP/glucagon receptor agonists, a potential novel treatment strategy in Alzheimer's disease. Expert Opin Investig Drugs. 2018 Nov 27. doi: 10.1080/13543784.2019.1552677.

 

  • SalasHuetos A, Moraleda R, Giardina S, Anton E, Blanco J, Salas-Salvadó J, Bulló M*. Effect of nut consumption on semen quality and functionality in healthy men consuming a Westernstyle diet: a randomized controlled trial. Am J Clin Nutr. 2018 Nov 1;108(5):953-962. doi: 10.1093/ajcn/nqy181. 

 

  • MallorquíBagué N, Lozano-Madrid M, Toledo E, Corella D, Salas-Salvadó J, Cuenca-Royo A, Vioque J, Romaguera D, Martínez JA, Wärnberg J, López-Miranda J, Estruch R, Bueno-Cavanillas A, Alonso-Gómez Á, Tur JA, Tinahones FJ, Serra-Majem  L, Martín V, Lapetra J, Vázquez C, Pintó X, Vidal J, Daimiel L, Gaforio JJ, Matía P, Ros E, Granero R, BuilCosiales P, Barragán R, Bulló M, Castañer O, Garcíade-la-Hera M, Yáñez AM, Abete I, García-Ríos A, Ruiz-Canela M, Díaz-López A, Jiménez-Murcia S, Martínez-González MA, De la Torre R, Fernández-Aranda F. Type 2 diabetes and cognitive impairment in an older population with overweight or obesity and metabolic syndrome: baseline cross-sectional analysis of the PREDIMED-plus study. Sci Rep. 2018 Oct 31;8(1):16128. doi: 10.1038/s41598-018-33843-8

 

  • Papandreou C, Bulló M,* et al Plasma trimethylamineN-oxide and related metabolites are associated with type 2 diabetes risk in the Prevención con Dieta Mediterránea (PREDIMED) trial. Am J Clin Nutr. 2018 Jul 1;108(1):163-173.

 

  • HernándezAlonso P, Giardina S, Cañueto D, Salas-Salvadó J, Cañellas N, Bulló M*. Changes in Plasma Metabolite Concentrations after a LowGlycemic Index Diet Intervention. Mol Nutr Food Res. 2018 Mar 30:e1700975.

 

  • GarcíaGavilán JF, Bulló M*, CamachoBarcia L, Rosique-Esteban N, Hernández-Alonso P, Basora J, Martínez-González MA, Estruch R, Fitó M, Salas-Salvadó J. Higher dietary glycemic index and glycemic load values increase  the risk of osteoporotic fracture in the PREvención con DIeta MEDiterránea (PREDIMED)Reus trial. Am J Clin Nutr. 2018 Jun 1;107(6):1035-1042.

 

  • Papandreou C, Bulló M*, Zheng Y, RuizCanela M, Yu E, Guasch-Ferré M, Toledo E, Clish C, Corella D, Estruch R, Ros E, Fitó M, Arós F, Fiol M, Lapetra J, Serra-Majem L, Gómez-Gracia E, Liang L, Fragkiadakis GA, Razquin C, Hu FB, Salas-Salvadó J. Plasma trimethylamine-N-oxide and related metabolites are associated with type 2 diabetes risk in the Prevención con Dieta Mediterránea (PREDIMED) trial. Am J Clin Nutr. 2018 Jul 1;108(1):163-173.

 

  • Giardina S, SalaVila A, Hernández-Alonso P, Calvo C, Salas-Salvadó J, Bulló M*. Carbohydrate quality and quantity affects the composition of the red blood cell fatty acid membrane in overweight and obese individuals. Clin Nutr. 2018, 37(2):481487. doi: 10.1016/j.clnu.2017.02.006

 

  • Giardina S, HernándezAlonso P, Díaz-López A, Salas-Huetos A, Salas-Salvadó J, Bulló M*. Changes in circulating miRNAs in healthy overweight and obese subjects: Effect of diet composition and weight loss. Clin Nutr. 2017 S02615614(17)31412-7.

 

  • Giardina S, HernándezAlonso P, Salas-Salvadó J, Rabassa-Soler A, Bulló M* Modulation of Human Subcutaneous Adipose Tissue MicroRNA Profile Associated with Changes in AdiposityRelated Parameters. Mol Nutr Food Res. 2018 Jan;62(2)

 

  • GarcíaGavilán J, Bulló M*, Canudas S, MartínezGonzález M, Estruch R, Giardina S, Fitó M, Corella D, Ros E, Salas-Salvadó J. Extra Virgin Olive Oil Consumption Reduces The Risk of Osteoporotic Fractures in The Predimed Trial. Clin Nutr. 2018 Feb;37(1):329335. doi: 10.1016/j.clnu.2016.12.030.

 

  • CamachoBarcia ML, Bulló M*, GarciaGavilán JF, Ruiz-Canela M, Corella D, Estruch R, Fitó M, García-Layana A, Arós F, Fiol M, Lapetra J, Serra-Majem L, Pintó X, García-Arellano A, Vinyoles E, Sorli JV, Salas-Salvadó J. Association of Dietary Vitamin K1 Intake With the Incidence of Cataract Surgery in an Adult Mediterranean Population: A Secondary Analysis of a Randomized Clinical Trial. JAMA Ophthalmol. 2017 Jun 1;135(6):657661.

 

  • HernándezAlonso P, Giardina S, Salas-Salvadó J, Arcelin P, Bulló M*. Chronic pistachio intake modulates circulating microRNAs related to glucose metabolism and insulin resistance in prediabetic subjects. Eur J Nutr. 2016 Jul 6. PMID: 27383196