In the last  years, our research group have been focused on the study of the relationship between lifestyle, mainly diet, and the cardiometabolic health, deeply focusing on the biochemichal and molecular mechanisms that could explain this relation. Demosntrating benefits of the Mediterranean Diet and different key foods of this healthy pattern on the development of cardiovascular disease and type 2 diabetes are important contributions from our group. Moreover, we are interested in the effect of lifestyle on changes in circulating metabolome, microbiota and epigenome.More recently, and due to the relation between diet and lifestyle on mental health, we have started a new line of research aimed to identify the relationship between diet and cognitive impairment besides to characterize the mechanisms underlying this relation.

Papandreou C, Arija V, Aretouli E, Tsilidis KK, Bulló M. Comparing eating behaviours, and symptoms of depression and anxiety between Spain and Greece during the COVID-19 outbreak: Cross-sectional analysis of two different confinement strategies. Eur Eat Disord Rev. 2020 Nov;28(6):836-846. doi: 10.1002/erv.2772. Epub 2020 Aug 4.

Barclay AW, Augustin LSA, Brighenti F, Delport E, Henry CJ, Sievenpiper JL, Usic K, Yuexin Y, Zurbau A, Wolever TMS, Astrup A, Bulló M, Buyken A, Ceriello A, Ellis PR, Vanginkel MA, Kendall CWC, La Vecchia C, Livesey G, Poli A, Riccardi G, Salas-Salvadó J, Trichopoulou A, Bhaskaran K, Jenkins DJA, Willett WC, Brand-Miller JC. Dietary Glycaemic Index Labelling: A Global Perspective. Nutrients. 2021 Sep 17;13(9):3244. doi: 10.3390/nu13093244.

Fuentes GC, Castañer O, Warnberg J, Subirana I, Buil-Cosiales P, Salas-Salvadó J, Corella D, Serra-Majem L, Romaguera D, Estruch R, Martínez JA, Pintó X, Vázquez C, Vidal J, Tur JA, Arós F, Bullo M, Fitó M, Schröder H. Prospective association of physical activity and inflammatory biomarkers in older adults from the PREDIMED-Plus study with overweight or obesity and metabolic syndrome. Clin Nutr. 2020 Oct;39(10):3092-3098. doi: 10.1016/j.clnu.2020.01.015. Epub 2020 Feb 3.

Papandreou C, Hernández-Alonso P, Bulló M, Ruiz-Canela M, Li J, Guasch-Ferré M, Toledo E, Clish C, Corella D, Estruch R, Cofán M, Fitó M, Razquin C, Arós F, Fiol M, Santos-Lozano JM, Serra-Majem L, Liang L, Martínez-González MA, Hu FB, Salas-Salvadó J. High Plasma Glutamate and a Low Glutamine-to-Glutamate Ratio Are Associated with Increased Risk of Heart Failure but Not Atrial Fibrillation in the Prevención con Dieta Mediterránea (PREDIMED) Study. J Nutr. 2020 Nov 19;150(11):2882-2889. doi: 10.1093/jn/nxaa273.

Papandreou C, Bulló M, Hernández-Alonso P, Ruiz-Canela M, Li J, Guasch-Ferré M, Toledo E, Clish C, Corella D, Estruch R, Ros E, Fitó M, Alonso-Gómez A, Fiol M, Santos-Lozano JM, Serra-Majem L, Liang L, Martínez-González MA, Hu FB, Salas-Salvadó J. Choline Metabolism and Risk of Atrial Fibrillation and Heart Failure in the PREDIMED Study. Clin Chem. 2021 Jan 8;67(1):288-297. doi: 10.1093/clinchem/hvaa224.

Salas-Huetos A, James ER, Salas-Salvadó J, Bulló M, Aston KI, Carrell DT, Jenkins TG. Sperm DNA methylation changes after short-term nut supplementation in healthy men consuming a Western-style diet.Andrology. 2021 Jan;9(1):260-268. doi: 10.1111/andr.12911. Epub 2020 Nov 3.

Bulló M, Papandreou C, Ruiz-Canela M, Guasch-Ferré M, Li J, Hernández-Alonso P, Toledo E, Liang L, Razquin C, Corella D, Estruch R, Ros E, Fitó M, Arós F, Fiol M, Serra-Majem L, Clish CB, Becerra-Tomás N, Martínez-González MA, Hu FB, Salas-Salvadó J. Plasma Metabolomic Profiles of Glycemic Index, Glycemic Load, and Carbohydrate Quality Index in the PREDIMED Study. J Nutr. 2021 Jan 4;151(1):50-58. doi: 10.1093/jn/nxaa345.

Muñoz-Garach A, Cornejo-Pareja I, Martínez-González MÁ, Bulló M, Corella D, Castañer O, Romaguera D, Vioque J, Alonso-Gómez ÁM, Wärnberg J, Martínez JA, Serra-Majem L, Estruch R, Bernal-López MR, Lapetra J, Pintó X, Tur JA, López-Miranda J, Bueno-Cavanillas A, Delgado-Rodríguez M, Matía-Martín P, Daimiel L, Sánchez VM, Vidal J, Prieto L, Ros E, Fernández-Aranda F, Camacho-Barcia L, Ortega-Azorin C, Soria M, Fiol M, Compañ-Gabucio L, Goicolea-Güemez L, Pérez-López J, Goñi N, Pérez-Cabrera J, Sacanella E, Fernández-García JC, Miró-Moriano L, Gimenez-Gracia M, Razquin C, Paz-Graniel I, Guillem P, Zomeño MD, Moñino M, Oncina-Canovas A, Salaverria-Lete I, Toledo E, Salas-Salvadó J, Schröder H, Tinahones FJ; Predimed-Plus Investigators. Milk and Dairy Products Intake Is Related to Cognitive Impairment at Baseline in Predimed Plus Trial. Mol Nutr Food Res. 2021 Apr;65(7):e2000728. doi: 10.1002/mnfr.202000728. Epub 2021 Mar 5.

García-Gavilán JF, Martínez A, Konieczna J, Mico-Perez R, García-Arellano A, Basora J, Barrubés L, Goday A, Canudas S, Salas-Salvadó J, Bulló M. U-Shaped Association between Dietary Acid Load and Risk of Osteoporotic Fractures in 2 Populations at High Cardiovascular Risk. J Nutr. 2021 Jan 4;151(1):152-161. doi: 10.1093/jn/nxaa335.

Camacho-Barcia L, García-Gavilán J, Papandreou C, Hansen TT, Harrold JA, Finlayson G, Blundell JE, Sjödin A, Halford JCG, Bulló M. Circulating Metabolites Associated with Postprandial Satiety in Overweight/Obese Participants: The SATIN Study. Nutrients. 2021 Feb 8;13 (2):549. doi: 10.3390/nu13020549.

Canudas S, HernándezAlonso P, Galié S, Muralidharan J, Morell-Azanza L, Zalba G, García-Gavilán J, Martí A, Salas-Salvadó J, Bulló M*. Pistachio consumption modulates DNA oxidation and genes related to telomere maintenance: a crossover randomized clinical trial. Am J Clin Nutr. 2019 Jun 1;109(6):17381745. doi: 10.1093/ajcn/nqz048.

Papandreou C, HernándezAlonso P, Bulló M, RuizCanela M, Yu E, Guasch-Ferré M, Toledo E, Dennis C, Deik A, Clish C, Razquin C, Corella D, Estruch R, Ros E, Fitó M, Arós F, Fiol M, Lapetra J, Ruano C, Liang L, Martínez-González MA, Hu FB, Salas-Salvadó J. Plasma Metabolites Associated with Coffee Consumption: A Metabolomic Approach within the PREDIMED Study. Nutrients. 2019 May 8;11(5). pii: E1032. doi: 10.3390/nu11051032.

Muralidharan J, Papandreou C, SalaVila A, Rosique-Esteban N, Fitó M, Estruch R, Angel Martínez-González M, Corella D, Ros E, Razquín C, Castañer O, Salas-Salvadó J, Bulló M*. Fatty Acids Composition of Blood Cell Membranes and Peripheral Inflammation in the PREDIMED Study: A CrossSectional Analysis. Nutrients. 2019 Mar 7;11(3). pii: E576. doi: 10.3390/nu11030576.

Papandreou C, Li J, Liang L, Bulló M, Zheng Y, RuizCanela M, Yu E, Guasch-Ferré M, Razquin C, Clish C, Corella D, Estruch R, Ros E, Fitó M, Arós F, Serra-Majem L, Rosique N, Martínez-González MA, Hu FB, Salas-Salvadó J. Metabolites related to purine catabolism and risk of type 2 diabetes incidence; modifying effects of the TCF7L2-rs7903146 polymorphism. Sci Rep. 2019 Feb 27;9(1):2892. doi: 10.1038/s41598-019-39441-6.

Papandreou C, Bulló M*, RuizCanela M, Dennis C, Deik A, Wang D, Guasch-Ferré M, Yu E, Razquin C, Corella D, Estruch R, Ros E, Fitó M, Fiol M, Liang L, Hernández-Alonso P, Clish CB, Martínez-González MA, Hu FB, Salas-Salvadó J. Plasma metabolites predict both insulin resistance and incident type 2 diabetes: a metabolomics approach within the Prevención con Dieta Mediterránea (PREDIMED) study. Am J Clin Nutr. 2019 Mar 1;109(3):626-634. doi: 10.1093/ajcn/nqy262.

Papandreou C, SalaVila A, Galié S, Muralidharan J, Estruch R, Fitó M, Razquin C, Corella D, Ros E, Timiraos J, Lapetra J, Serra-Majem L, Carlos S, Castañer O, Asensio EM, Salas-Salvadó J, Bulló M*. Association Between Fatty Acids of Blood Cell Membranes and Incidence of Coronary Heart Disease. Arterioscler Thromb Vasc Biol. 2019 Apr;39(4):819825. doi: 10.1161/ATVBAHA.118.312073.

Camins A, Ettcheto M, Busquets O, Manzine PR, CastroTorres RD, Beas-Zarate C, Verdaguer E, Sureda FX, Bulló M, Olloquequi J, Auladell C, Folch J. Triple GLP1/GIP/glucagon receptor agonists, a potential novel treatment strategy in Alzheimer's disease. Expert Opin Investig Drugs. 2018 Nov 27. doi: 10.1080/13543784.2019.1552677.

SalasHuetos A, Moraleda R, Giardina S, Anton E, Blanco J, Salas-Salvadó J, Bulló M*. Effect of nut consumption on semen quality and functionality in healthy men consuming a Westernstyle diet: a randomized controlled trial. Am J Clin Nutr. 2018 Nov 1;108(5):953-962. doi: 10.1093/ajcn/nqy181. 

MallorquíBagué N, Lozano-Madrid M, Toledo E, Corella D, Salas-Salvadó J, Cuenca-Royo A, Vioque J, Romaguera D, Martínez JA, Wärnberg J, López-Miranda J, Estruch R, Bueno-Cavanillas A, Alonso-Gómez Á, Tur JA, Tinahones FJ, Serra-Majem  L, Martín V, Lapetra J, Vázquez C, Pintó X, Vidal J, Daimiel L, Gaforio JJ, Matía P, Ros E, Granero R, BuilCosiales P, Barragán R, Bulló M, Castañer O, Garcíade-la-Hera M, Yáñez AM, Abete I, García-Ríos A, Ruiz-Canela M, Díaz-López A, Jiménez-Murcia S, Martínez-González MA, De la Torre R, Fernández-Aranda F. Type 2 diabetes and cognitive impairment in an older population with overweight or obesity and metabolic syndrome: baseline cross-sectional analysis of the PREDIMED-plus study. Sci Rep. 2018 Oct 31;8(1):16128. doi: 10.1038/s41598-018-33843-8

Papandreou C, Bulló M,* et al Plasma trimethylamineN-oxide and related metabolites are associated with type 2 diabetes risk in the Prevención con Dieta Mediterránea (PREDIMED) trial. Am J Clin Nutr. 2018 Jul 1;108(1):163-173.

HernándezAlonso P, Giardina S, Cañueto D, Salas-Salvadó J, Cañellas N, Bulló M*. Changes in Plasma Metabolite Concentrations after a LowGlycemic Index Diet Intervention. Mol Nutr Food Res. 2018 Mar 30:e1700975.

GarcíaGavilán JF, Bulló M*, CamachoBarcia L, Rosique-Esteban N, Hernández-Alonso P, Basora J, Martínez-González MA, Estruch R, Fitó M, Salas-Salvadó J. Higher dietary glycemic index and glycemic load values increase  the risk of osteoporotic fracture in the PREvención con DIeta MEDiterránea (PREDIMED)Reus trial. Am J Clin Nutr. 2018 Jun 1;107(6):1035-1042.

Papandreou C, Bulló M*, Zheng Y, RuizCanela M, Yu E, Guasch-Ferré M, Toledo E, Clish C, Corella D, Estruch R, Ros E, Fitó M, Arós F, Fiol M, Lapetra J, Serra-Majem L, Gómez-Gracia E, Liang L, Fragkiadakis GA, Razquin C, Hu FB, Salas-Salvadó J. Plasma trimethylamine-N-oxide and related metabolites are associated with type 2 diabetes risk in the Prevención con Dieta Mediterránea (PREDIMED) trial. Am J Clin Nutr. 2018 Jul 1;108(1):163-173.

Giardina S, SalaVila A, Hernández-Alonso P, Calvo C, Salas-Salvadó J, Bulló M*. Carbohydrate quality and quantity affects the composition of the red blood cell fatty acid membrane in overweight and obese individuals. Clin Nutr. 2018, 37(2):481487. doi: 10.1016/j.clnu.2017.02.006

Giardina S, HernándezAlonso P, Díaz-López A, Salas-Huetos A, Salas-Salvadó J, Bulló M*. Changes in circulating miRNAs in healthy overweight and obese subjects: Effect of diet composition and weight loss. Clin Nutr. 2017 S02615614(17)31412-7.

Giardina S, HernándezAlonso P, Salas-Salvadó J, Rabassa-Soler A, Bulló M* Modulation of Human Subcutaneous Adipose Tissue MicroRNA Profile Associated with Changes in AdiposityRelated Parameters. Mol Nutr Food Res. 2018 Jan;62(2)

GarcíaGavilán J, Bulló M*, Canudas S, MartínezGonzález M, Estruch R, Giardina S, Fitó M, Corella D, Ros E, Salas-Salvadó J. Extra Virgin Olive Oil Consumption Reduces The Risk of Osteoporotic Fractures in The Predimed Trial. Clin Nutr. 2018 Feb;37(1):329335. doi: 10.1016/j.clnu.2016.12.030.

CamachoBarcia ML, Bulló M*, GarciaGavilán JF, Ruiz-Canela M, Corella D, Estruch R, Fitó M, García-Layana A, Arós F, Fiol M, Lapetra J, Serra-Majem L, Pintó X, García-Arellano A, Vinyoles E, Sorli JV, Salas-Salvadó J. Association of Dietary Vitamin K1 Intake With the Incidence of Cataract Surgery in an Adult Mediterranean Population: A Secondary Analysis of a Randomized Clinical Trial. JAMA Ophthalmol. 2017 Jun 1;135(6):657661.

HernándezAlonso P, Giardina S, Salas-Salvadó J, Arcelin P, Bulló M*. Chronic pistachio intake modulates circulating microRNAs related to glucose metabolism and insulin resistance in prediabetic subjects. Eur J Nutr. 2016 Jul 6.