Lead researcher: Francisco Tinahones Madueño

Research Center: Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de la Victoria, Málaga

The group belongs to the Endocrinology and Nutrition Clinical Unit of the Virgen de la Victoria University Hospital, within the area of Cardiovascular and Renal Diseases - Diabetes and Obesity of IBIMA. The lines of research focus on the study of metabolic diseases, through different approaches, always with a translational approach. In recent years, special interest has been given to the study of environmental factors, microbiota and epigenetics, in the development of this type of pathologies. In line with this network, our group has the following lines of research focused on the study of genetics, the environment and epigenetics in the context of chronic non communicable diseases such as obesity, diabetes and related metabolic disorders, and cancer, as well as the search for new biomarkers and therapeutic targets:

    01. Intestinal microflora, insulin resistance and obesity

    02. Adipobiology in subjects with obesity-diabetes discordant phenotypes

    03. Metabolic effect of bariatric surgery

    04. Environmental factors in the genesis of obesity and diabetes

    05. New mechanisms in the obesity/cancer relationship

    06. PREDIMED PLUS Study


1: Gomez-Huelgas R, Ruiz-Nava J, Santamaria-Fernandez S, Vargas-Candela A, Alarcon-Martin AV, Tinahones FJ, Bernal-Lopez MR. Impact of Intensive Lifestyle Modification on Levels of Adipokines and Inflammatory Biomarkers in Metabolically Healthy Obese Women. Mediators Inflamm. 2019 Apr 9;2019:4165260. doi: 10.1155/2019/4165260. eCollection 2019. PubMed PMID: 31093012; PubMed Central PMCID: PMC6481026. 

2: Cornejo-Pareja I, Martín-Núñez GM, Roca-Rodríguez MM, Cardona F, Coin-Aragüez  L, Sánchez-Alcoholado L, Gutiérrez-Repiso C, Muñoz-Garach A, Fernández-García JC, Moreno-Indias I, Tinahones FJ. H. pylori Eradication Treatment Alters Gut Microbiota and GLP-1 Secretion in Humans. J Clin Med. 2019 Apr 4;8(4). pii: E451. doi: 10.3390/jcm8040451. PubMed PMID: 30987326; PubMed Central PMCID: PMC6517938. 

3: Ramos-Molina B, Queipo-Ortuño MI, Lambertos A, Tinahones FJ, Peñafiel R. Dietary and Gut Microbiota Polyamines in Obesity- and Age-Related Diseases. Front Nutr. 2019 Mar 14;6:24. doi: 10.3389/fnut.2019.00024. eCollection 2019. Review. PubMed PMID: 30923709; PubMed Central PMCID: PMC6426781. 

4: Gutiérrez-Repiso C, Moreno-Indias I, de Hollanda A, Martín-Núñez GM, Vidal J,  Tinahones FJ. Gut microbiota specific signatures are related to the successful rate of bariatric surgery. Am J Transl Res. 2019 Feb 15;11(2):942-952. eCollection 2019. PubMed PMID: 30899393; PubMed Central PMCID: PMC6413284. 

5: Martín-Núñez GM, Cornejo-Pareja I, Coin-Aragüez L, Roca-Rodríguez MDM, Muñoz-Garach A, Clemente-Postigo M, Cardona F, Moreno-Indias I, Tinahones FJ. H.  pylori eradication with antibiotic treatment causes changes in glucose homeostasis related to modifications in the gut microbiota. PLoS One. 2019 Mar 14;14(3):e0213548. doi: 10.1371/journal.pone.0213548. eCollection 2019. PubMed PMID: 30870471; PubMed Central PMCID: PMC6417676. 

6: Castellano-Castillo D, Morcillo S, Crujeiras AB, Sánchez-Alcoholado L, Clemente-Postigo M, Torres E, Tinahones FJ, Macias-Gonzalez M. Association between serum 25-hydroxyvitamin D and global DNA methylation in visceral adipose  tissue from colorectal cancer patients. BMC Cancer. 2019 Jan 21;19(1):93. doi: 10.1186/s12885-018-5226-4. PubMed PMID: 30665376; PubMed Central PMCID: PMC6341579. 

7: Macías-González M, Martín-Núñez GM, Garrido-Sánchez L, García-Fuentes E, Tinahones FJ, Morcillo S. Decreased blood pressure is related to changes in NF-kB promoter methylation levels after bariatric surgery. Surg Obes Relat Dis. 2018 Sep;14(9):1327-1334. doi: 10.1016/j.soard.2018.06.011. Epub 2018 Jun 23. PubMed PMID: 30057095. 

8: Castellano-Castillo D, Morcillo S, Clemente-Postigo M, Crujeiras AB, Fernandez-García JC, Torres E, Tinahones FJ, Macias-Gonzalez M. Adipose tissue inflammation and VDR expression and methylation in colorectal cancer. Clin Epigenetics. 2018 Apr 25;10:60. doi: 10.1186/s13148-018-0493-0. eCollection 2018. PubMed PMID: 29719581; PubMed Central PMCID: PMC5921388. 

9: Crujeiras AB, Morcillo S, Diaz-Lagares A, Sandoval J, Castellano-Castillo D, Torres E, Hervas D, Moran S, Esteller M, Macias-Gonzalez M, Casanueva FF, Tinahones FJ. Identification of an episignature of human colorectal cancer associated with obesity by genome-wide DNA methylation analysis. Int J Obes (Lond). 2019 Jan;43(1):176-188. doi: 10.1038/s41366-018-0065-6. Epub 2018 May 1.  PubMed PMID: 29717273.