Cardiometabolic diseases are the main cause of death in the world and excess diet and bad lifestyle habits contribute to the development of this type of disease. Our aim is to understand how different non-coding RNAs regulate lipid metabolism during states of health and disease, developing new strategies, both pharmacological and dietary, in order to modulate their function. On the other hand, we also focus on the search for therapeutic alternatives for the control of microbiota through the activity of non-coding RNAs, both host and exogenous (dietary) RNAs.

Specifically, we aimed to:

Generate new basic knowledge of how non-coding RNAs regulate the metabolism of lipids under physiological and pathological conditions.

Find and evaluate minor dietary components for their ability to modulate the activity of non-coding RNAs associated with the metabolism of lipids.

Incorporate the use non-coding RNAs data to develop Precision Nutrition.
Focus on understanding of lifestyle modification of the epigenome in order to try to personalize the health of individuals using epigenetics for the development of Precision Nutrition.

Focus on understanding of lifestyle modification of the epigenome in order to try to personalize the health of individuals using epigenetics for the development of Precision Nutrition.

Test ncRNAs as therapeutic alternative to target the Microbiota, both from the host and exogenous (dietary).

 Chapado LA; Martín-Hernández R; Hernández de la Red S; et al; Dávalos
A. 2021. Connection between miRNA Mediation and the Bioactive Effects of Broccoli
( Brassica oleracea var. italica): Exogenous miRNA Resistance to Food Processing and GI
Digestion Journal of Agricultural and Food Chemistry. 69-32, pp.9326-9337.
 

Mantilla-Escalante DC; López de Las Hazas MC; Crespo MC; et al;
Dávalos A. 2021. Mediterranean diet enriched in extra-virgin olive oil or nuts modulates
circulating exosomal non-coding RNAs European Journal of Nutrition.
 

 Martín-Hernández R; Rodríguez-Canul R; Nuvia; et al; Olivera-Castillo
L. 2021. Comparative Transcriptomes of the Body Wall of Wild and Farmed Sea Cucumber
Isostichopus badionotus Int. J. Mol. Sci.
 

 Del Pozo-Acebo L; López de Las Hazas MC; Tomé-Carneiro J;
Gil-Cabrerizo P; San-Cristobal R; Busto R; García-Ruiz A; Dávalos A. 2021. Bovine
Milk-Derived Exosomes as a Drug Delivery Vehicle for miRNA-Based Therapy Int J Mol Sci.
5 Scientific paper. Gil-Zamorano J; Tomé-Carneiro J,; Lopez de Las Hazas MC; et al;
Dávalos A. 2020. Intestinal miRNAs regulated in response to dietary lipids Scientific
Reports.

Cansanção K; Citelli M; Carvalho Leite N; López de Las Hazas
MC; Dávalos A; Tavares do Carmo MDG; Peres WAF. 2020. Impact of Long-Term
Supplementation with Fish Oil in Individuals with Non-Alcoholic Fatty Liver Disease: A
Double Blind Randomized Placebo Controlled Clinical Trial Nutrients.
 

Fernández-Sanjurjo M,; Úbeda N; Fernández-García B,; et al; Dávalos
A. 2020. Exercise dose affects the circulating microRNA profile in response to acute
endurance exercise in male amateur runners Scand J Med Sci Sports.
 

López de Las Hazas MC; Gil-Zamorano J; Cofán M; et al; Dávalos
A. 2020. One-year dietary supplementation with walnuts modifies exosomal miRNA in
elderly subjects European Journal of Nutrition.
 

 López de Las Hazas MC; Iglesias-Carres L; Mantilla-Escalante D; et al;
Dávalos A. 2020. Exosomes transport trace amounts of (poly)phenols Food and Funtion.
 

Ruiz-Roso MB; Gil-Zamorano J; López de Las Hazas MC; et al; Dávalos
A. 2020. Intestinal Lipid Metabolism Genes Regulated by miRNAs Frontiers in Genetics.
 

López de Las Hazas MC; Martin-Hernández R; Crespo MC; et al; Dávalos
A. 2019. Identification and validation of common molecular targets of hydroxytyrosol Food
and Funtion. 10-8, pp.4897-4910.
 

Visioli F; Dávalos A; López de Las Hazas MC; Crespo MC; Tomé-Carneiro
J. 2019. An overview of the pharmacology of olive oil and its active ingredients British
Journal of Pharmacology.
 

 Martín-Hernández R; Reglero G; Ordovàs JM; Dávalos
A. 2019. NutriGenomeDB: a nutrigenomics exploratory and analytical platform Database.
 

Sales RC; Medeiros PDC; Spreafico F; et al; das Graças Tavares
do Carmo M. 2019. Olive Oil, Palm Oil, and Hybrid Palm Oil Distinctly Modulate Liver
Transcriptome and Induce NAFLD in Mice Fed a High-Fat Diet Int J Mol Sci. 20(1): 8.
 

Mantilla-Escalante DC; López de Las Hazas MC; Gil-Zamorano J; et
al; Dávalos A. 2019. Postprandial Circulating miRNAs in Response to a Dietary Fat
Challenge.Nutrients. 13;11(6).