Epigenetics of lipid metabolism group (DISLIPID)

Foto Epigenetics of lipid metabolism group (DISLIPID)

Lead researcher: Alberto Dávalos

Research Center: IMDEA Alimentación. Laboratorio de epigenética del metabolismo lipídico

Phone: +34 917278100 ext 206

Cardiometabolic diseases are the main cause of death in the world and excess diet and bad lifestyle habits contribute to the development of this type of disease. Our aim is to understand how different non-coding RNAs regulate lipid metabolism during states of health and disease, developing new strategies, both pharmacological and dietary, in order to modulate their function. On the other hand, we also focus on the search for therapeutic alternatives for the control of microbiota through the activity of non-coding RNAs, both host and exogenous (dietary) RNAs.


Specifically, we aimed to:

Generate new basic knowledge of how non-coding RNAs regulate the metabolism of lipids under physiological and pathological conditions.

Find and evaluate minor dietary components for their ability to modulate the activity of non-coding RNAs associated with the metabolism of lipids.

Incorporate the use non-coding RNAs data to develop Precision Nutrition.
Focus on understanding of lifestyle modification of the epigenome in order to try to personalize the health of individuals using epigenetics for the development of Precision Nutrition.

Focus on understanding of lifestyle modification of the epigenome in order to try to personalize the health of individuals using epigenetics for the development of Precision Nutrition.

Test ncRNAs as therapeutic alternative to target the Microbiota, both from the host and exogenous (dietary).

 

  • Crespo MC, Tomé-Carneiro J, Gómez-Coronado D, Burgos-Ramos E, García-Serrano A, Martín-Hernández R, Baliyan S, Fontecha J, Venero C, Dávalos A, Visioli F. Modulation of miRNA expression in aged rat hippocampus by buttermilk and krill oil. Sci Rep. 2018 Mar 5;8(1):3993.

 

  • Spreafico F, Sales RC, Gil-Zamorano J, Medeiros PDC, Latasa MJ, Lima MR, de Souza SAL, Martin-Hernández R, Gómez-Coronado D, Iglesias-Gutierrez E, Mantilla-Escalante DC, das Graças Tavares do Carmo M, Dávalos A. Dietary supplementation with hybrid palm oil alters liver function in the common Marmoset. Sci Rep. 2018 Feb 9;8(1):2765.

 

  • Tomé-Carneiro J, Fernández-Alonso N, Tomás-Zapico C, Visioli F, Iglesias-Gutierrez E, Dávalos A. Breast milk microRNAs harsh journey towards potential effects in infant development and maturation. Lipid encapsulation can help. Pharmacol Res. 2018 Apr 5; 132:21-32.

 

  • Martín-Hernández R, Reglero G, Dávalos A. Data mining of nutrigenomics experiments: identification of a cancer protective gene signature. J Funct Foods. 2018; 42:380-386.