Lipids and Nutrigenomic Department. Arteriosclerosis and Metabolic Syndrome. GC09

Foto Lipids and Nutrigenomic Department. Arteriosclerosis and Metabolic Syndrome. GC09

Lead researcher: José López Miranda

Research Center: Hospital Universitario Reina Sofía – Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC). Av. Menéndez Pidal s/n. Córdoba. España.

Phone: +34 957 213734

The Nutrigenomics and Metabolic Syndrome research group is a consolidated group of IMIBIC, bringing together both basic and clinical researchers in various scientific disciplines, such as medicine, biology, biochemistry, as well as dieticians and nursing. Our research is mainly based on the effect of dietary components on cardiovascular risk through a double approach: the biological actions of the diet on mechanisms and factors related to the development of atherosclerosis (oxidative stress, inflammation, homeostasis or cellular signaling) and Nutrigenetics, through which we investigate how common genetic variants modulate the influence of the diet on different markers such as postprandial metabolism, endothelial function, overweight or glucose metabolism. We are also interested in the use of these strategies in others pathologies such as hypercholesterolemia, thromboembolic disease, as well as in ageing process. These approaches will allow us to modulate the pathological pathways that underlie the development of various chronic diseases (type 2 diabetes mellitus, metabolic syndrome and cardiovascular diseases).

Over the last few years, our group has been developing predictive models for assessing the risk of disease. Specifically, we are developing innovative models to evaluate biological senescence, coronary heart disease treatment choice and miRNAs plasma levels-based model for type 2 diabetes mellitus development. Moreover, due to the complex nature of gene-environment interactions, another important aim of our research is to establish an appropriate dietary therapy in according to the disease, for personalized nutrition.

Our research group is highly motivated toward internationalization. In fact, we are currently taking part in two international consortiums. POWER2DM, whose objective is to develop individual self-control of diabetes; and FAME, for the identification of new disease biomarkers.

  • GomezMarin B, Gomez-Delgado F, Lopez-Moreno J, Alcala-Diaz JF, Jimenez-Lucena R, Torres-Pena JD, Garcia-Rios A, Ortiz-Morales AM, Yubero-Serrano EM, Malagon MD, Lai CQ, Delgado-Lista J, Ordovas JM, Lopez-Miranda J, Perez-Martinez P. Long-term consumption of a Mediterranean diet improves postprandial lipemia in patients with type 2 diabetes: the Cordioprev randomized trial. AMERICAN JOURNAL OF CLINICAL NUTRITION. 2018; 108(5):963-970. IF: 6,549   Q1   D1.


  • JimenezLucena R, Rangel-Zuniga OA, Alcala-Diaz JF, Lopez-Moreno J, Roncero-Ramos I, Molina-Abril H, Yubero-Serrano EM, Caballero-Villarraso J, Delgado-Lista J, Castano JP, Ordovas JM, Perez-Martinez P, Camargo A, Lopez-Miranda J. Circulating miRNAs as Predictive Biomarkers of Type 2 Diabetes Mellitus Development in Coronary Herat Disease Patients from the CORDIOPREV Study. MOLECULAR THERAPY-NUCLEIC ACIDS. 2018; 12:146-157. IF: 5,66   Q1   D1.


  • GarciaRios A, Alcala-Diaz JF, Gomez-Delgado F, Delgado-Lista J, Marin C, Leon-Acuna A, Camargo A, Rodriguez-Cantalejo F, Blanco-Rojo R, Quintana-Navarro G, Ordovas JM, Perez-Jimenez F, Lopez-Miranda J, Perez-Martinez P. Beneficial effect of CETP gene polymorphism in combination with a Mediterranean diet influencing lipid metabolism in metabolic syndrome patients: CORDIOPREV study. CLINICAL NUTRITION. 2018; 37(1):229-234. IF: 5,496   Q1   D1


  • Roncero-Ramos I, Rangel-Zuniga OA, Lopez-Moreno J, Alcala-Diaz JF, Perez-Martinez P, Jimenez-Lucena R, Castano JP, Roche HM, Delgado-Lista J, Ordovas JM, Camargo A, Lopez-Miranda J. Mediterranean Diet, Glucose Homeostasis, and Inflammasome Genetic Variants: The CORDIOPREV Study. MOLECULAR NUTRITION & FOOD RESEARCH. 2018; 62(9):Núm artículo 1700960.IF: 5,151   Q1   D1


  • JimenezLucena R, Camargo A, Alcala-Diaz JF, Romero-Baldonado C, Luque RM, van Ommen B, Delgado-Lista J, Ordovas JM, Perez-Martinez P, Rangel-Zuniga OA, Lopez-Miranda J. A plasma circulating miRNAs profile predicts type 2 diabetes mellitus and prediabetes: from the CORDIOPREV study. EXPERIMENTAL AND MOLECULAR MEDICINE. 2018; 50:Núm artículo 168. IF: 5,584   Q1.


  • Corina A, RangelZúñiga OA, Jiménez-Lucena R, Alcalá-Díaz JF, Quintana-Navarro G, Yubero-Serrano EM, López-Moreno J, Delgado-Lista J, Tinahones F, Ordovás JM, López-Miranda J, Pérez-Martínez P. Low Intake of Vitamin E Accelerates Cellular Aging in Patients With Established Cardiovascular Disease: The CORDIOPREV Study. J GERONTOL A BIOL SCI MED SCI. 2019. 16;74(6).


  • GomezDelgado F, Delgado-Lista J, Lopez-Moreno J, Rangel-Zuniga OA, Alcala-Diaz JF, Leon-Acuna A, Corina A, Yubero-Serrano E, Torres-Pena JD, Camargo A, Garcia-Rios A, Caballero J, Castano J, Ordovas JM, Lopez-Miranda J, Perez-Martinez P. Telomerase RNA Component Genetic Variants Interact With the Mediterranean Diet Modifying the Inflammatory Status and its Relationship With Aging: CORDIOPREV Study. JOURNALS OF GERONTOLOGY SERIES ABIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2018; 73(3):327332. IF: 4,902   Q1


  • LopezMoreno J, Quintana-Navarro GM, Delgado-Lista J, Garcia-Rios A, Alcala-Diaz JF, Gomez-Delgado F, Camargo A, Perez-Martinez P, Tinahones FJ, Striker GE, Perez-Jimenez F, Villalba JM, Lopez-Miranda J, Yubero-Serrano EM. Mediterranean Diet Supplemented With Coenzyme Q(10) Modulates the Postprandial Metabolism of Advanced Glycation End Products in Elderly Men and Women. JOURNALS OF GERONTOLOGY SERIES ABIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2018; 73(3):340-346.IF: 4,902   Q1
  • Roncero-Ramos I, Jimenez-Lucena R, Alcala-Diaz JF, Vals-Delgado C, Arenas-Larriva AP, Rangel-Zuniga OA, Leon-Acuna A, Malagon MM, Delgado-Lista J, Perez-Martinez P, Ordovas JM, Camargo A, Lopez-Miranda J. Alpha cell function interacts with diet to modulate prediabetes and Type 2 diabetes. JOURNAL OF NUTRITIONAL BIOCHEMISTRY. 2018; 62:247256. IF: 4,414   Q1


  • Torres-Pena JD, Garcia-Rios A, Delgado-Casado N, Gomez-Luna P, Alcala-Diaz JF, Yubero-Serrano EM, Gomez-Delgado F, Leon-Acuna A, Lopez-Moreno J, Camargo A, Tinahones FJ, Delgado-Lista J, Ordovas JM, Perez-Martinez P, Lopez-Miranda J. Mediterranean diet improves endothelial function in patients with diabetes and prediabetes: A report from the CORDIOPREV study. ATHEROSCLEROSIS. 2018; 269:50-56. IF: 4,467   Q1


  • Santos-Marcos, JA; Rangel-Zuniga, OA; Jimenez-Lucena, R; Quintana-Navarro, GM; Garcia-Carpintero, S; Malagon, MM; Landa, BB; Tena-Sempere, M; Perez-Martinez, P; Lopez-Miranda, J; Perez-Jimenez, F; Camargo, A. Influence of gender and menopausal status on gut microbiota. MATURITAS. 2018; 116:43-53. IF: 3,315   Q1