Our group is focused on developing dietary and / or nutritional strategies that use bacteria, or compounds capable of modulating the microbiota profile and its activity, to maintain or restore the intestinal microbial balance and promote health. Our strengths are based on our extensive experience in microbial physiology, which allows us to characterize the functional and technological properties of a wide variety of microorganisms, and to address studies on probiotics, food microbiota and human microbiota. Our knowledge of functional genomics and bioinformatics allows us to carry out projects of bacterial genomics, proteomics and transcriptomics, as well as metagenomics of complex populations. On the other hand, to study the interactions between bacteria, the microbiota and the host, we have implemented several in vitro and in vivo models, including models with immortalized cell lines, immune cells and human tissues, as well as preclinical models in animals. We have also developed methods to study the bioavailability of nutrients and bioactives. The group develops its projects from a multidisciplinary perspective, counting on national and international collaborations including medical doctors, immunologists, nutritionists, chemists and bioinformatics, among others.
The main objective of our research group is to generate knowledge about the functions carried out by food and intestinal microorganisms in relation to human health. To achieve this general objective, we are developing different lines of research:
- Line 1. Functionality of microorganisms and probiotic foods
- Line 2. Interactions of intestinal microorganisms with the host and with technological challenges
- Line 3. Collection, preservation, and culture of faecal microbiota
- Line 4. Role of the microbiota in different physiological and pathological states: dysbiosis, microbial markers of disease and strategies to modulate the microbiota
- Line 5. Development of bioinformatic tools for the study of the functionality of microbiota and probiotics.