One of our research groups at Nutriepigen has described a new procedure that allows the selective modification of the human intestinal microbiota by using antibodies raised against surface-associated bacterial proteins specific to the microorganism of interest. 

For this purpose, a polyclonal antibody was developed that recognizes the surface-associated protein Protein A of Lactobacillus acidophilus DSM20079T. Using fluorescent probes and magnetic particles, we were able to specifically identify this bacterium in both synthetic and real microbiota.
Furthermore, we demonstrated the applicability of this antibody to eliminate L. acidophilus complex human intestinal microbiota in a single step, as well as the interaction with other bacteria in both synthetic and real microbiota.
With the discovery of single-species killing of the gut microbiota, using antibodies that recognize specific cell surface elements of the target organism, will open new avenues to address research on the specific immunomodulatory and metabolic contributions of a bacterium of interest in the context of a complex human gut microbiota.

Picture taken from: prebioticoyprobioticos.com

For more infromation: https://www.nature.com/articles/s41598-020-80187-3