05Oct
Imagen blog de Did you know that eating tomatoes in-season can prevent oxidative stress?

Did you know that eating tomatoes in-season can prevent oxidative stress?

The results from our latest study entitled “Tomatoes consumed in-season prevent oxidative stress in Fischer 344 rats: impact of geographical origin”, seems to indicate this. The aim of this study was to evaluate the antioxidant properties of tomatoes consumed in-season from two different geographical origins (local LT or non-local NLT) in Fischer 344 rats.

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05Oct
Imagen blog de A set of miRNAs predicts T2DM remission in patients with coronary heart disease: from the CORDIOPREV study

A set of miRNAs predicts T2DM remission in patients with coronary heart disease: from the CORDIOPREV study

MicroRNAs (miRNAs) regulate the expression of genes associated with the development of diseases, including type 2 diabetes mellitus (T2DM). However, the use of miRNAs to predict T2DM remission has been poorly studied. Therefore, we aimed to investigate whether circulating miRNAs could be used to predict the probability of T2DM remission in patients with coronary heart disease.

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05Oct
Imagen blog de 25-Hydroxyvitamin D status is associated with interleukin-6 methylation in adipose tissue from patients with colorectal cancer

25-Hydroxyvitamin D status is associated with interleukin-6 methylation in adipose tissue from patients with colorectal cancer

Our study suggests a possible association between epigenetic regulation of inflammatory mediators of visceral adipose tissue (VAT) in the context of colorectal cancer (CRC). This situation could be regulated, in part, by serum 25 (OH) D, as we observed an association between IL6 methylation and CRC risk, through 25 (OH) D. IL6 expression in VAT is a good prognostic factor for CRC, suggesting that IL6 could be an interesting target at HAT levels for CRC prevention.

 

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05Oct
Imagen blog de An Epigenetic Signature is Associated with Serum 25-Hydroxyvitamin D in Colorectal Cancer Tumors

An Epigenetic Signature is Associated with Serum 25-Hydroxyvitamin D in Colorectal Cancer Tumors

This is the first study of its kind to report a decrease in global DNA methylation in subjects with low 25 (OH) D in the context of colorectal cancer (CRC).
 

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05Oct
Imagen blog de Precision modification of the human gut microbiota targeting surface-associated proteins

Precision modification of the human gut microbiota targeting surface-associated proteins

One of our research groups at Nutriepigen has described a new procedure that allows the selective modification of the human intestinal microbiota by using antibodies raised against surface-associated bacterial proteins specific to the microorganism of interest. 

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28Sep
Imagen blog de Connection between miRNA Mediation and the Bioactive Effects of Broccoli (Brassica oleracea var. italica): Exogenous miRNA Resistance to Food Processing and GI Digestion

Connection between miRNA Mediation and the Bioactive Effects of Broccoli (Brassica oleracea var. italica): Exogenous miRNA Resistance to Food Processing and GI Digestion

As we know, healthy dietary habits reduce the risk of developing chronic diseases (e.g., heart disease, stroke and diabetes). A large number of studies support the preventive role of certain fruits and vegetables containing a variety of bioactive compounds in the development of these diseases. Recent findings provide evidence of how bioactive compounds (such as vitamins, lipids, miRNAs or other metabolites) present in the diet may exert their biological activity affecting consumer gene expression patterns.

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13Aug
Imagen blog de Go eat berries!

Go eat berries!

In our previous blog we mentioned bioactive compounds, and surely more than one of you have heard them somewhere.

Well, bioactive compounds are molecules that are present in foods such as fruits, vegetables and milk. They are not considered nutrients, but they have a physiological effect and therefore can have a beneficial effect on health.

These compounds can be found in the supermarket, right on the fruit shelves, and as a curious fact, these molecules are related to the color of fruits, for example the blue and red of berries.

So when you feel like eating berries for their exquisite flavor, remember that they also possess bioactive compounds such as anthocyanins, which according to the research we share today, have a beneficial effect on cardiovascular health.

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15Apr
Imagen blog de Did you know that the sea has cucumbers?

Did you know that the sea has cucumbers?

Yes, the sea has cucumbers! but they are not the ones we eat in our salads. 

Sea cucumbers (Isostichopus badionotus) are echinoderms, like starfish and sea urchins.  There are about 1,250 known species, and many of these animals are characterized by the shape of soft-bodied cucumbers.
Apart from their shape, in recent years, sea cucumbers have attracted attention for their properties in traditional medicine and as a food supplement.

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04May
Imagen blog de Linking APOA2 rs3813627 SNP to HDL and APOA1 through BMI

Linking APOA2 rs3813627 SNP to HDL and APOA1 through BMI

APOA2 is part of the apolipoprotein superfamily that includes the apolipoprotein A1 and is the second most common apolipoprotein on the human HDL.  It has been considered of minor physiological importance in lipoprotein metabolism, recent studies in rodent models have shown that APOA2 plays multiple roles in the maintenance of HDL, obesity, and blood glucose.

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03Feb
Imagen blog de Conjugated Physiological Resveratrol Metabolites Induce Senescence in Breast Cancer Cells: Role of p53/P21 and p16/Rb Pathways, and ABC Transporters

Conjugated Physiological Resveratrol Metabolites Induce Senescence in Breast Cancer Cells: Role of p53/P21 and p16/Rb Pathways, and ABC Transporters

Every year, about 1.5 million new breast cancer (BC) cases are diagnosed in women worldwide. This high incidence has aroused the interest of the scientific community, placing BC in the spotlight. The prevention or treatment of this chronic disease through diet is one of the most explored strategies hitherto. Resveratrol (RSV) is one of the most investigated phenolic compounds in the last decades.

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18Dec
Imagen blog de Urolithin metabotypes can anticipate the different restoration of the gut microbiota and anthropometric profiles during the first year postpartum

Urolithin metabotypes can anticipate the different restoration of the gut microbiota and anthropometric profiles during the first year postpartum

Gut microbiota composition greatly varies among individuals. Some bacterial groups can metabolize dietary polyphenols, such as the ellagitannins occurring in walnuts, pomegranate, strawberries, etc., which are metabolized to the final molecules so-called urolithins (Uros). These metabolites exert in vivo anti-inflammatory, cardioprotective, and neuroprotective activity.

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19Nov
Imagen blog de  Dietary Factors, Epigenetics and their Implications for Human Obesity

Dietary Factors, Epigenetics and their Implications for Human Obesity

Obesity has reached a pandemic scale worldwide, mainly caused by changes in lifestyles that include the regular consumption of high-calorie food and a critical reduction of physical activity. There is now a growing body of evidence that suggests that epigenetic mechanisms may underlie the development of metabolic disorders associated to obesity.

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19Nov
Imagen blog de RESISTANCE TRAINING AS ANTI-AGING THERAPY

RESISTANCE TRAINING AS ANTI-AGING THERAPY

Researchers from University of Oviedo have recently published a study where the importance of autophagy, a crucial process for cellular proteaostasis maintenance which decrease with age, is analyzed within the context of resistance or endurance training adaptations.

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03Oct
Imagen blog de New Study Reveals Development of Pathogenic Bacteria in Children Born by Caesarean Section

New Study Reveals Development of Pathogenic Bacteria in Children Born by Caesarean Section

A group of researchers in the United Kingdom recently published a study in which it was found that babies born by cesarean section experience changes in their microbiome with respect to babies born vaginally.

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18Sep
Imagen blog de Eva mitocondrial, la -madre- de todos los seres humanos

Eva mitocondrial, la -madre- de todos los seres humanos

En un viejo número de Science Dialy tienen un buen artículo sobre genética y uno de los «personajes históricos» más curiosos de los que se pueda hablar, la Eva mitocondrial o «primigenia»: ‘Mitochondrial Eve’: Mother of all humans lived 200,000 years ago. Esta curiosa figura –a la que más o menos apropiadamente pusieron el nombre de la primera mujer del Génesis– sería, estadísticamente hablando, el ancestro común más reciente por línea materna de todos los seres humanos que hoy en día vivimos sobre la Tierra.

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01Jan

Stool microRNA profiles reflect different dietary and gut microbiome patterns in healthy individuals

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