04May
Imagen blog de Linking APOA2 rs3813627 SNP to HDL and APOA1 through BMI

Linking APOA2 rs3813627 SNP to HDL and APOA1 through BMI

APOA2 is part of the apolipoprotein superfamily that includes the apolipoprotein A1 and is the second most common apolipoprotein on the human HDL.  It has been considered of minor physiological importance in lipoprotein metabolism, recent studies in rodent models have shown that APOA2 plays multiple roles in the maintenance of HDL, obesity, and obesity-related insulin resistance.

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03Feb
Imagen blog de Conjugated Physiological Resveratrol Metabolites Induce Senescence in Breast Cancer Cells: Role of p53/P21 and p16/Rb Pathways, and ABC Transporters

Conjugated Physiological Resveratrol Metabolites Induce Senescence in Breast Cancer Cells: Role of p53/P21 and p16/Rb Pathways, and ABC Transporters

Every year, about 1.5 million new breast cancer (BC) cases are diagnosed in women worldwide. This high incidence has aroused the interest of the scientific community, placing BC in the spotlight. The prevention or treatment of this chronic disease through diet is one of the most explored strategies hitherto. Resveratrol (RSV) is one of the most investigated phenolic compounds in the last decades.

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08Jan
Imagen blog de Metabolic profiling of dietary polyphenols and methylxanthines in normal and malignant mammary tissues from breast cancer patients: The POLYSEN trial

Metabolic profiling of dietary polyphenols and methylxanthines in normal and malignant mammary tissues from breast cancer patients: The POLYSEN trial

Previous studies suggest that dietary polyphenols and(or) their metabolites can exert beneficial effects against breast cancer. We usually consume in the diet, methylxanthines (caffeine, theobromine, etc.), with stimulant and cardioprotective properties, among others. However, it is unknown whether polyphenols can reach human malignant breast tumors in molecular forms and(or) at concentrations likely to act against cancer.

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18Dec
Imagen blog de Urolithin metabotypes can anticipate the different restoration of the gut microbiota and anthropometric profiles during the first year postpartum

Urolithin metabotypes can anticipate the different restoration of the gut microbiota and anthropometric profiles during the first year postpartum

Gut microbiota composition greatly varies among individuals. Some bacterial groups can metabolize dietary polyphenols, such as the ellagitannins occurring in walnuts, pomegranate, strawberries, etc., which are metabolized to the final molecules so-called urolithins (Uros). These metabolites exert in vivo anti-inflammatory, cardioprotective, and neuroprotective activity.

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19Nov
Imagen blog de  Dietary Factors, Epigenetics and their Implications for Human Obesity

Dietary Factors, Epigenetics and their Implications for Human Obesity

Obesity has reached a pandemic scale worldwide, mainly caused by changes in lifestyles that include the regular consumption of high-calorie food and a critical reduction of physical activity. There is now a growing body of evidence that suggests that epigenetic mechanisms may underlie the development of metabolic disorders associated to obesity.

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19Nov
Imagen blog de RESISTANCE TRAINING AS ANTI-AGING THERAPY

RESISTANCE TRAINING AS ANTI-AGING THERAPY

Researchers from University of Oviedo have recently published a study where the importance of autophagy, a crucial process for cellular proteaostasis maintenance which decrease with age, is analyzed within the context of resistance or endurance training adaptations.

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03Oct
Imagen blog de New Study Reveals Development of Pathogenic Bacteria in Children Born by Caesarean Section

New Study Reveals Development of Pathogenic Bacteria in Children Born by Caesarean Section

A group of researchers in the United Kingdom recently published a study in which it was found that babies born by cesarean section experience changes in their microbiome with respect to babies born vaginally.

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18Sep
Imagen blog de Eva mitocondrial, la -madre- de todos los seres humanos

Eva mitocondrial, la -madre- de todos los seres humanos

En un viejo número de Science Dialy tienen un buen artículo sobre genética y uno de los «personajes históricos» más curiosos de los que se pueda hablar, la Eva mitocondrial o «primigenia»: ‘Mitochondrial Eve’: Mother of all humans lived 200,000 years ago. Esta curiosa figura –a la que más o menos apropiadamente pusieron el nombre de la primera mujer del Génesis– sería, estadísticamente hablando, el ancestro común más reciente por línea materna de todos los seres humanos que hoy en día vivimos sobre la Tierra.

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